R3 (Recurrence-Risk Ratio) [ previous song / next song ]

written by Do Peterson

Do: Lead and Background Vocals, Electric Guitars, Groove Box, Drum Machine, Synth | Tanya Shaffer: Background Vocals

I'm introducing here λ_{S}, | Widely used for linkage analysis, | Often used in genetic epi studies. | This our parameter of interest, | A ratio that I'll use for my test, | A ratio comparing situations. | If this risk ratio is greater than one | Is evidence disease is family sprung, | Is evidence disease is aggregated | In families; we use the sibling pairs | To try to find relationship is there | Significantly within family structure. | The probability that you are affected | Given your sib'ling is also affected | Compared to population prevalence | Of the disease. | Please, let me introduce the | Recurrence-risk ratio... | ...for siblings | ...Risch 1990 | ...AJHG | ...Articles I, II and III. | Marker data from affected sibling pairs | Make up an estimate risk ratio, where | We test a null of no genetic linkage. | When we reject the null hypothesis, | λ_{S} greater than 1 shows us | Some evidence disease and marker locus linked. | The probability that you are affected | Given your sib'ling is also affected | Compared to population prevalence | Of the disease. | Please, let me introduce the | Recurrence-risk ratio... | ...for siblings | ...Risch 1990 | ...AJHG | ...Articles I, II and III.